Lunch with the Chancellor


Leslie, Ling, and Alana were able to attend a luncheon with the Chancellor celebrating mentor/mentee relationships between women.

First Year Graduate Student Rotation: Abby Shelton

Abby Shelton is a first year graduate student interested in cancer genetics. She
has just completed a rotation in the Parise lab, where she worked with graduate student Alex Chung. She has now moved on to her third rotation, where she is studying drug resistance in glioblastoma. She will choose her program and thesis lab at the end of the semester.

“I worked closely with Alex to explore the molecular mechanisms of CIB1 addiction in triple negative breast cancer. We are hoping that CIB1, a calcium integrin binding protein, can be used as a therapeutic target in combination with traditional chemotherapeutic drugs to increase drug efficacy and decrease toxic side effects. It is an especially attractive target because cancer cells require it for survival, while healthy cells do not. I utilized cell culture and Western blot techniques to explore the mechanism of death in CIB1-depleted cells.” -Abby Shelton

We wish you the best!


Laila Presents at 2016 ASH Conference

Congratulations to Laila Elsherif for presenting her work at the 2016 American Society of Hematology (ASH)  Conference. Her collaborative work with Josh Cooper, Carrington Metts, and Dr. Parise is titled Quantification of Suicidal Netosis Using Convolutional Neural Networks in Human Neutrophils.

neutrophil conference

pictured left to right: Carrington Metts, Laila Elsherif, Josh Cooper, Leslie Parise

First Year Graduate Student Rotation: Karel Alcedo

Karel Alcedo is a first year graduate student in the Biochemistry and Biophysics program. She is currently wrapping up her last week of her rotation experience in the Parise lab.

“We use conveimg_0772ntional trypan blue staining to identify dead cells in a very robust manner; however, it can be very time consuming and it may compromise cell viability when analyzing multiple samples . Our project necessitates a high throughput method to analyze the samples in a very quick and robust manner without compromising viability. Thus, we have developed a pan-cell death assay using trypan blue in flow cytometry. This assay will provide a tool to evaluate the efficacy of a combination therapy using CIB1 depletion and Docetaxel against TNBC cell lines in vitro.” Karel Alcedo

In addition to presenting her research to the lab this week she will be presenting her research findings at UNC’s graduate symposium for first year students on November 14th. We wish Karel the best in her future endeavors!

Congratulations to Laila Elsheif on her acceptance of the 2016 Development Faculty Award. In addition, her abstract has been accepted for the 2016 American Society of Hematology Meeting titled Quantification of Suicidal Netosis Using Convolutional Neural Networks in Human Neutrophils.

Justin Black Thesis Defense

Justin's Talk
Justin’s Talk

Justin Black gave a seminar based on his doctoral dissertation titled “Exploration of the Role of CIB1 in Cell Survival and Tumor Growth.” His research  demonstrates the importance of CIB1 in survival and tumor growth of triple negative breast cancer (TNBC) cell lines.

Saying good bye to his beloved bench.
Saying good bye to his beloved bench.


Justin joined the Parise Lab in 2012 and has been a valuable member of our group for the last three years. After the graduation, Justin will be working  for a biotechnology company  in Boston.

Congratulations, Dr. Justin Black!

XXV ISTH Congress in Toronto, Canada

ISTH 2015 Toronto

Leslie Parise, Steve Holly, and Laila Elsherif attended the International Society on Thrombosis and Haemostasis  (ISTH) Congress held in Toronto, Canada on June 20-25.

Steve Holly gave an oral presentation titled “Chemoproteomic discovery of novel anti-platelet targets.”

Laila Elsherif had a poster presentation titled ” The Leukocyte integrin Beta2 primes neutrophils for netosis in sickle cell disease. “

Happy Graduation to Christina and Melissa!

Undergraduate students Christina and Melissa both graduated from UNC Chapel Hill on May 10th.

Christina and Steve
Christina and Steve

Christina Wang  majored in Chemistry and joined Parise lab at the beginning of her Junior year. She has been working on a platelet project with Steve Holly.

Mel and Justin
Mel and Justin


Melissa Fellmeth majored in Biology and joined Parise lab at the beginning of her Senior year. She has been working on a CIB1 project with Justin Black.

Thank you for all the hard work and contribution to the Parise Lab research projects. Wishing you all the best in your future endeavors!

Summer Undergraduate Students

The Parise Lab welcomes two summer undergraduate students, Davia and Anna!

Davia Blake

Davia Blake is a rising Senior majoring in Chemistry from Virginia Polytechnic Institute and State University. She is a participant of the 2014 Summer Research Program in Biophysics and visiting the Carolina for the summer. Davia is working with Steve Holly on Platelet Research.


Anna Tang  is a undergraduate student from UNC-Chapel Hill majoring in Chemistry and Mathematics. She has joined the Parise Lab for the summer to gain experience in medical research. Anna is working with Justin Black on CIB1 Project.

Steve Holly and Thomas Freeman at ASBMB Annual meeting

Steve Holly and Thomas Freeman presented at  the 2014 American Society of Biochemistry and Molecular Biology (ASBMB) Annual Meeting held in San Diego, CA on April 26-30.

Dr. Steve Holly gave an oral presentation of his latest research titled

 “Discovery of a lipid deacetylase (AADACL1) as a novel regulator of platelet activation.”

Steve 2014 ASBMB

Dr. Thomas Freeman presented a research poster titled

” Protein-protein interactions between CIB1 and novel integrin binding partners: structural and thermodynamic basis of CIB1 promiscuity.

Thomas 2014 ASBMB